Benzoyl chloride → N-(5-chloro-2-methyl-4-nitrophenyl)benzamide

HRID 605292ノート

反応式

HRID 605292 の反応式
[Cl:1][C:2]1[C:3]([N+:10]([O-:12])=[O:11])=[CH:4][C:5]([CH3:9])=[C:6]([NH2:8])[CH:7]=1.[C:13](Cl)(=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[C:3]([N+:10]([O-:12])=[O:11])=[CH:4][C:5]([CH3:9])=[C:6]([NH:8][C:13](=[O:20])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:7]=1

参加物

4

反応物 2

HCID 7412Benzoyl chlorideHCID 837726-Chloro-4-nitro-o-toluidine

生成物 1

HCID 4158578N-(5-chloro-2-methyl-4-nitrophenyl)benzamide収率 32%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of 5-chloro-2-methyl-4-nitrophenylamine (0.560 g, 3.00 mmol) and benzoyl chloride (0.422 g, 3.00 mmol) in toluene (15 mL) was heated under reflux for 1.5 h, and cooled to room temperature. A solid crystallized from the reaction mixture upon cooling, and was isolated by vacuum filtration and dried to provide the title compound as a gray solid (0.276 g, 32%).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 1.5 h
  3. customA solid crystallized from the reaction mixture
  4. temperatureupon cooling
  5. customwas isolated by vacuum filtration
  6. customdried

出典と根拠

ORDレコード
ord-ddf67a31fca7406ab29e0738bd32721d
出典データセット
uspto-grants-2011_03
特許番号
US07910595B2

反応ノート

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