関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 4-Aminophenol | HCID 403 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | N-(4-bromophenyl)-4-chloro-3-nitrobenzamide | HCID 1068537 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-(4-Amino-phenoxy)-N-(4-bromo-phenyl)-3-nitro-benzamide | HCID 67040506 | 98.1% |
反応手順
A mixture of the product from Example 10A (3.55g, 10 mmol), 4-aminophenol (1.09 g, 10 mmol), and potassium hydroxide (1.12 g, 20 mmol) were dissolved in dimethyl sulfoxide (15 mL) and heated at 100° C. in a CEM Discover microwave for 25 minutes. The mixture was then cooled to room temperature, poured into water (300 mL), the pH of the solution adjusted to 6 with 1N aqueous hydrochloric acid, the resultant solution stirred for 30 minutes and the resultant solid collected and dried to provide the title compound as a yellow solid (4.2 g, 98%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07910595B2 |
|---|
| 出典データセット | uspto-grants-2011_03 |
|---|
| ORD ID | ord-d3d78c4f4fe34b559b89262890ea832d |
|---|
| 出典メモ | uspto-grants-2011_03 |
|---|
