Ammonium Chloride → (S)-1-(2-Bromophenyl)ethanamine

HRID 605338ノート

反応式

HRID 605338 の反応式
[N:1]([C@H:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[Br:12])[CH3:5])=[N+]=[N-].[NH4+].[Cl-].[In]>CCO.O>[Br:12][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=1[C@@H:4]([NH2:1])[CH3:5]

参加物

5

反応物 3

HCID 25517Ammonium ChlorideHCID 5359967IndiumHCID 866155641-[(1S)-1-azidoethyl]-2-bromobenzene

生成物 1

HCID 2530257(S)-1-(2-Bromophenyl)ethanamine収率 88%

試薬・触媒・溶媒 1

HCID 19096565Water ethanol溶媒

実験手順

To a solution of (S)-1-(1-azidoethyl)-2-bromobenzene (45 mg, 0.2 mmol) in EtOH/H2O (5 mL/5 mL) was added in NH4Cl (108 mg, 2.0 mmol) and indium (91 mg, 0.8 mmol). The mixture was refluxed overnight. The reaction mixture was filtered, washed with EtOH and evaporated. The residue was triturated with AcOEt and filtered. The filtrate was evaporated to give the title compound (35 mg, 88%).

後処理

  1. temperatureThe mixture was refluxed overnight
  2. filtrationThe reaction mixture was filtered
  3. washwashed with EtOH
  4. customevaporated
  5. customThe residue was triturated with AcOEt
  6. filtrationfiltered
  7. customThe filtrate was evaporated

出典と根拠

ORDレコード
ord-041214f9c7a8431296a83e4f76dac554
出典データセット
uspto-grants-2011_03
特許番号
US07910595B2

反応ノート

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