化工社化工社 化学情報印刷レポート · 研究参考用
(S)-(-)-N,alpha-Dimethylbenzylamine → (S)-(4-{2-(7-Isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-4-[methyl-(1-phenyl-ethyl)-carbamoyl]-phenylsulfanyl}-phenyl)-carbamic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (S)-(-)-N,alpha-Dimethylbenzylamine | HCID 2060073 | — |
| 反応物 | 4-(4-tert-Butoxycarbonylamino-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzoic acid | HCID 59376892 | — |
| 生成物 | (S)-(4-{2-(7-Isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-4-[methyl-(1-phenyl-ethyl)-carbamoyl]-phenylsulfanyl}-phenyl)-carbamic acid tert-butyl ester | HCID 67040484 | 54% |
反応手順
According to the procedure in Example 385F, the title compound was prepared using 4-(4-tert-butoxycarbonylamino-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzoic acid (prepared in Example 385E) and (S)-N,α-dimethylbenzylamine: yield 54%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07910595B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-bd8c6c82429c418099117afb3d68214f |
| 出典メモ | uspto-grants-2011_03 |