4-(4-tert-Butoxycarbonylamino-phenylsulfanyl)-3-nitro-benzoic acid methyl ester → Methyl 3-amino-4-(4-(methoxycarbonylamino)phenylthio)benzoate

HRID 605402ノート

反応式

HRID 605402 の反応式
[CH3:1][O:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([S:12][C:13]2[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][C:14]=2[N+:23]([O-])=O)=[CH:8][CH:7]=1)=[O:4].COC(=O)C1C=CC(SC2C=CC(NC(OC(C)(C)C)=O)=CC=2)=C([N+]([O-])=O)C=1>>[NH2:23][C:14]1[CH:15]=[C:16]([CH:21]=[CH:22][C:13]=1[S:12][C:9]1[CH:10]=[CH:11][C:6]([NH:5][C:3]([O:2][CH3:1])=[O:4])=[CH:7][CH:8]=1)[C:17]([O:19][CH3:20])=[O:18]

参加物

3

反応物 2

HCID 593768704-(4-tert-Butoxycarbonylamino-phenylsulfanyl)-3-nitro-benzoic acid methyl esterHCID 67041007Methyl 4-(4-(methoxycarbonylamino)phenylthio)-3-nitrobenzoate

生成物 1

HCID 67040749Methyl 3-amino-4-(4-(methoxycarbonylamino)phenylthio)benzoate収率 88%

実験手順

The title compound was prepared by the procedure in Example 385C substituting the product from Example 441A for the product of Example 385B. The reaction was purified by silica gel chromatography (ethyl acetate/CHCl3=1/9) to give the title compound (yield 88%).

後処理

  1. customThe title compound was prepared by the procedure in Example 385C
  2. customThe reaction was purified by silica gel chromatography (ethyl acetate/CHCl3=1/9)

出典と根拠

ORDレコード
ord-e156897df9164f93ad499a016bae9f56
出典データセット
uspto-grants-2011_03
特許番号
US07910595B2

反応ノート

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