4-Fluoro-2-(trifluoromethyl)benzoyl chloride → N-(3-Cyclopentyl-1-hydroxy-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-4-fluoro-2-trifluoromethyl-benzamide

HRID 60544

反応式

HRID 60544 の反応式
[CH:1]1([CH:6]2[O:10][B:9]([OH:11])[C:8]3[CH:12]=[C:13]([NH:16][C:17](=[O:28])[C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=4[C:24]([F:27])([F:26])[F:25])[CH:14]=[CH:15][C:7]2=3)[CH2:5][CH2:4][CH2:3][CH2:2]1.[F:29]C(F)(F)C1C=C(F)C=CC=1C(Cl)=O>>[CH:1]1([CH:6]2[O:10][B:9]([OH:11])[C:8]3[CH:12]=[C:13]([NH:16][C:17](=[O:28])[C:18]4[CH:23]=[CH:22][C:21]([F:29])=[CH:20][C:19]=4[C:24]([F:27])([F:25])[F:26])[CH:14]=[CH:15][C:7]2=3)[CH2:2][CH2:3][CH2:4][CH2:5]1

参加物

3

反応物 2

HCID 6056804-Fluoro-2-(trifluoromethyl)benzoyl chlorideHCID 66927470N-(3-Cyclopentyl-1-hydroxy-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-2-trifluoromethyl-benzamide

生成物 1

HCID 67359293N-(3-Cyclopentyl-1-hydroxy-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-4-fluoro-2-trifluoromethyl-benzamide

実験手順

The title compound was prepared using a procedure similar to that of N-(3-cyclopentyl-1-hydroxy-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-2-trifluoromethyl-benzamide with 2-trifluoromethyl-4-fluorobenzoyl chloride replacing 2-trifluoromethylbenzoyl chloride. Data: LCMS (M/Z): 430 (M+23); 1H NMR (acetone) δ: 9.64 (br. s., 1H), 8.14 (d, J=1.9 Hz, 1H), 7.83 (dd, J=8.5, 5.4 Hz, 1H), 7.71 (dd, J=8.2, 2.0 Hz, 1H), 7.50-7.64 (m, 2H), 7.39 (d, J=8.2 Hz, 1H), 5.13 (d, J=4.8 Hz, 1H), 2.25-2.37 (m, J=8.2, 8.2, 8.2, 8.2, 4.8 Hz, 1H), 1.82-1.92 (m, 1H), 1.62-1.74 (m, 2H), 1.44-1.59 (m, 3H), 1.30-1.40 (m, 1H), 1.10-1.19 (m, 1H).

出典と根拠

ORDレコード
ord-a19452d45b384905a76fd0394b7d6f5d
出典データセット
uspto-grants-2016_09
特許番号
US09440994B2

関連ノート

読み込み中…