反応式
[CH:1]1([CH:6]2[O:10][B:9]([OH:11])[C:8]3[CH:12]=[C:13]([NH:16][C:17](=[O:28])[C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=4[C:24]([F:27])([F:26])[F:25])[CH:14]=[CH:15][C:7]2=3)CCCC1.[F:29]C(F)(F)C1C=C(F)C=CC=1C(Cl)=O.[CH2:43]([Mg]Br)[CH:44]([CH3:46])C>>[F:29][C:21]1[CH:22]=[CH:23][C:18]([C:17]([NH:16][C:13]2[CH:14]=[CH:15][C:7]3[CH:6]([CH2:1][CH:44]([CH3:46])[CH3:43])[O:10][B:9]([OH:11])[C:8]=3[CH:12]=2)=[O:28])=[C:19]([C:24]([F:25])([F:26])[F:27])[CH:20]=1参加物
4
反応物 3
生成物 1
実験手順
The title compound was prepared using a procedure similar to that of N-(3-cyclopentyl-1-hydroxy-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-2-trifluoromethyl-benzamide with 2-trifluoromethyl-4-fluorobenzoyl chloride replacing 2-trifluoromethylbenzoyl chloride, and with isobutyl magnesium bromide replacing cyclopentyl magnesium bromide. Data: LCMS (M/Z): 396 (M+H); 1H NMR (DMSO-d6) δ: 10.54 (s, 1H), 9.13 (s, 1H), 8.03 (d, J=1.8 Hz, 1H), 7.73-7.81 (m, 2H), 7.58-7.68 (m, 2H), 7.31 (d, J=8.2 Hz, 1H), 5.10 (dd, J=9.8, 3.1 Hz, 1H), 1.60-1.69 (m, 1H), 1.21-1.31 (m, 1H), 0.98 (d, J=6.5 Hz, 3H), 0.89 (d, J=6.7 Hz, 3H), 0.85 (t, J=7.0 Hz, 1H).
出典と根拠
- ORDレコード
- ord-a36b58957e0448a3acad5d0a1257ab5b
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09440994B2
関連ノート
読み込み中…