Water → 2,4-Dichloro-N-methoxy-N-methylbenzamide
反応式
Cl.[CH3:2][O:3][NH:4][CH3:5].C(N(CC)CC)C.[Cl:13][C:14]1[CH:22]=[C:21]([Cl:23])[CH:20]=[CH:19][C:15]=1[C:16](Cl)=[O:17].O>C(Cl)Cl>[Cl:13][C:14]1[CH:22]=[C:21]([Cl:23])[CH:20]=[CH:19][C:15]=1[C:16]([N:4]([O:3][CH3:2])[CH3:5])=[O:17]参加物
6
実験手順
A mixture of 32.6 g of N-methoxymethanamine hydrochloride and 91.2 ml of triethylamine in 500 ml of DCM is cooled in an ice bath, and then 47 ml of 2,4-dichlorobenzoyl chloride are added slowly and the mixture is left to stir while allowing the temperature to rise to AT. After stirring for 1 hour at AT, water is added to the reaction mixture, the mixture is extracted with DCM, the organic phase is dried over Na2SO4 and the solvent is evaporated under vacuum. 53 g of the expected compound are obtained.
後処理
- temperatureis cooled in an ice bath
- waitthe mixture is left
- additionis added to the reaction mixture
- extractionthe mixture is extracted with DCM
- dry with materialthe organic phase is dried over Na2SO4
- customthe solvent is evaporated under vacuum
出典と根拠
- ORDレコード
- ord-848fe4355e8c472db559bd1b7fe9dfa8
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07915258B2
反応ノート
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