Water → 2-Chloro-N-methoxy-N-methylbenzamide
反応式
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].Cl.[CH3:12][O:13][NH:14][CH3:15].C(N(CC)CC)C.O>C(Cl)Cl>[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([N:14]([O:13][CH3:12])[CH3:15])=[O:5]参加物
6
実験手順
50 ml of 2-chlorobenzoyl chloride are added slowly to a mixture of 37.33 g of N-methoxymethanamine hydrochloride and 104 ml of triethylamine in 500 ml of DCM and the mixture is left to stir overnight at AT. Water is added to the reaction mixture, the mixture is extracted with DCM, the organic phase is washed with a buffer solution pH=2 and dried over Na2SO4, and the solvent is evaporated off under vacuum. 78.57 g of the expected compound are obtained.
後処理
- waitthe mixture is left
- extractionthe mixture is extracted with DCM
- washthe organic phase is washed with a buffer solution pH=2
- dry with materialdried over Na2SO4
- customthe solvent is evaporated off under vacuum
出典と根拠
- ORDレコード
- ord-a2d3bd84d52348c9bdfe9e1ff8be64cf
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07915258B2
反応ノート
読み込み中…