Triphenylphosphine → (3-Cyanobenzyl)triphenylphosphonium bromide

HRID 605789ノート

反応式

HRID 605789 の反応式
[C:1]1([P:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:20]([C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=1)[CH2:25][Br:26])#[N:21]>>[Br-:26].[C:20]([C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=1)[CH2:25][P+:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)#[N:21]

参加物

3

反応物 2

HCID 11776TriphenylphosphineHCID 97249Benzonitrile, 3-(bromomethyl)-

生成物 1

HCID 2778355(3-Cyanobenzyl)triphenylphosphonium bromide収率 72.7%

反応条件

温度
80 °C

実験手順

Triphenylphosphine (2.8 g) was added to a Tol (50 ml) solution of 3-cyanobenzyl bromide (2.0 g), followed by stirring at 80° C. for 5 hours. This was cooled to room temperature, and the precipitated solid was collected by filtration, and washed with Tol. This was dried under reduced pressure to obtain (3-cyanobenzyl)(triphenyl)phosphonium bromide (3.4 g).

後処理

  1. temperatureThis was cooled to room temperature
  2. filtrationthe precipitated solid was collected by filtration
  3. washwashed with Tol
  4. customThis was dried under reduced pressure

出典と根拠

ORDレコード
ord-5ee4e84298684cc38906189079ebdf4a
出典データセット
uspto-grants-2011_03
特許番号
US07915261B2

反応ノート

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