Triphenylphosphine → Phosphonium, [[3-(methoxycarbonyl)phenyl]methyl]triphenyl-, bromide

HRID 605791

反応式

HRID 605791 の反応式
[C:1]1([P:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:20][CH2:21][C:22]1[CH:23]=[C:24]([CH:29]=[CH:30][CH:31]=1)[C:25]([O:27][CH3:28])=[O:26]>>[Br-:20].[CH3:28][O:27][C:25]([C:24]1[CH:23]=[C:22]([CH:31]=[CH:30][CH:29]=1)[CH2:21][P+:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)=[O:26]

参加物

3

反応物 2

HCID 11776TriphenylphosphineHCID 517981Methyl 3-(bromomethyl)benzoate

生成物 1

HCID 10051285Phosphonium, [[3-(methoxycarbonyl)phenyl]methyl]triphenyl-, bromide収率 100.3%

反応条件

温度
80 °C

実験手順

Triphenylphosphine (85.8 g) was added to a Tol (400 ml) solution of methyl 3-bromomethylbenzoate (50.0 g), followed by stirring at 80° C. for 10 hours. After this was cooled to room temperature, the crystal precipitated was collected by filtration and washed with Tol. This was dried under reduced pressure to obtain (3-methoxycarbonylbenzyl)(triphenyl)phosphonium bromide (107.6 g).

後処理

  1. temperatureAfter this was cooled to room temperature
  2. customthe crystal precipitated
  3. filtrationwas collected by filtration
  4. washwashed with Tol
  5. customThis was dried under reduced pressure

出典と根拠

ORDレコード
ord-e78920478d8f44d99091fe0c36185b41
出典データセット
uspto-grants-2011_03
特許番号
US07915261B2

関連ノート

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