Hydrochloric Acid → 2-(Pyrimidin-4-yl)benzoic acid hydrochloride

HRID 60584ノート

反応式

HRID 60584 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:16]=[CH:15][CH:14]=[CH:13][C:8]=2[C:9]([O:11]C)=[O:10])=[N:3][CH:2]=1.[ClH:17]>C(O)(=O)C>[ClH:17].[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:16]=[CH:15][CH:14]=[CH:13][C:8]=2[C:9]([OH:11])=[O:10])=[N:3][CH:2]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 86680852Methyl 2-(pyrimidin-4-yl)benzoate

生成物 1

HCID 866808532-(Pyrimidin-4-yl)benzoic acid hydrochloride

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of methyl 2-(pyrimidin-4-yl)benzoate (0.49 g), acetic acid (2.0 mL) and 6 N hydrochloric acid (10 mL) was heated under reflux for 5 hr. The solvent was evaporated under reduced pressure, and the obtained residue was washed with ethyl acetate to give the title compound (0.45 g).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 5 hr
  3. customThe solvent was evaporated under reduced pressure
  4. washthe obtained residue was washed with ethyl acetate

出典と根拠

ORDレコード
ord-64ad8669fdd7422f8bff69f46dec81c0
出典データセット
uspto-grants-2016_09
特許番号
US09440990B2

反応ノート

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