化工社化工社 化学情報印刷レポート · 研究参考用
1-Propanol → 5-(5-Bromo-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamino)-2-morpholin-4-yl-benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Propanol | HCID 1031 | — |
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 5,8-Dibromo-(1,2,4)triazolo(1,5-a)pyrazine | HCID 49758022 | — |
| 反応物 | 4-{8-[4-(4-Methyl-piperazin-1-yl)-phenylamino]-[1,2,4]triazolo[1,5-a]pyrazin-5-yl}-thiophene-2-carboxylic acid amide | HCID 57589928 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 5-(5-Bromo-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamino)-2-morpholin-4-yl-benzamide | HCID 57590053 | 73% |
反応手順
This compound may be prepared using methods as described for Compound 6, step 1 using 5,8-dibromo-[1,2,4]triazolo[1,5-a]pyrazine (250 mg, 0.90 mmol) 5-amino-2-morpholin-4-yl benzamide (299 mg, 1.35 mmol) and N,N-diisopropylethylamine (0.24 mL, 1.35 mmol) in 2-propanol (7 mL). Trituration with PrOH and Et2O affords the title compound (273 mg, 73%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07915256B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-107f71fcc5fa4c66a874357fe4a3f499 |
| 出典メモ | uspto-grants-2011_03 |