Methylamine → 4-Bromo-N-methylthiazole-2-carboxamide

HRID 605945ノート

反応式

HRID 605945 の反応式
C([O:3][C:4]([C:6]1[S:7][CH:8]=[C:9]([Br:11])[N:10]=1)=O)C.[CH3:12][NH2:13]>CO>[CH3:12][NH:13][C:4]([C:6]1[S:7][CH:8]=[C:9]([Br:11])[N:10]=1)=[O:3]

参加物

4

反応物 2

HCID 6329MethylamineHCID 49757955Ethyl 4-bromothiazole-2-carboxylate

生成物 1

HCID 575900864-Bromo-N-methylthiazole-2-carboxamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

4-Bromothiazole-2-carboxylic acid ethyl ester (500 mg, 2.13 mmol) is dissolved in methanol (1 mL) and methyl amine in methanol (10 mL) is added. The mixture is stirred overnight at room temperature. Evaporation of the solvent under reduced pressure affords the title compound as yellow solid. LCMS: Rt 0.92 min (100%) m/z (ESI) 219/221 (M+H)+.

後処理

  1. customEvaporation of the solvent under reduced pressure

出典と根拠

ORDレコード
ord-1ac158033ba34f7089024cf60db846ad
出典データセット
uspto-grants-2011_03
特許番号
US07915256B2

反応ノート

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