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llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0

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反応

3-Pyridinemethanamine → 4-(5-Bromo-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamino)-N-pyridin-3-ylmethyl-benzamide

HRID 605987

印刷プレビュー

反応式

HRID 605987 の反応式

[Br:1][C:2]1[N:7]2[N:8]=[CH:9][N:10]=[C:6]2[C:5]([NH:11][C:12]2[CH:20]=[CH:19][C:15]([C:16]([OH:18])=O)=[CH:14][CH:13]=2)=[N:4][CH:3]=1.ON1C2C=CC=CC=2N=N1.O.C(N=C=NCCCN(C)C)C.[N:43]1[CH:48]=[CH:47][CH:46]=[C:45]([CH2:49][NH2:50])[CH:44]=1>CN(C=O)C>[Br:1][C:2]1[N:7]2[N:8]=[CH:9][N:10]=[C:6]2[C:5]([NH:11][C:12]2[CH:13]=[CH:14][C:15]([C:16]([NH:50][CH2:49][C:45]3[CH:44]=[N:43][CH:48]=[CH:47][CH:46]=3)=[O:18])=[CH:19][CH:20]=2)=[N:4][CH:3]=1

参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 310183-Pyridinemethanamine

HCID 757711-Hydroxybenzotriazole

HCID 224003181-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide hydrate

HCID 575900854-(5-Bromo-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamino)-benzoic acid

生成物 1

HCID 575899444-(5-Bromo-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamino)-N-pyridin-3-ylmethyl-benzamide収率 82.3%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of 4-(5-bromo-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamino)-benzoic acid (0.230 g, 0.69 mmol), 3-hydroxybenzotriazole (0.103 g, 0.76 mmol), 1-ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrate (0.146 g, 0.76 mmol) in DMF (5 mL) and 3-picolylamine (0.077 mL, 0.76 mmol) is stirred at room temperature for 21 hours. The solvent is removed in vacuo and the residue is triturated with diethyl ether, ethyl acetate and dichloromethane. A pale yellow solid is obtained, washed with water and dried to afford the title compound (241 mg, 82%).

後処理

customThe solvent is removed in vacuo
customthe residue is triturated with diethyl ether, ethyl acetate and dichloromethane
customA pale yellow solid is obtained
washwashed with water
customdried

出典と根拠

ORDレコード: ord-6cf49f4e6021461d89033f020903bae1
出典データセット: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07915256B2

反応ノート

読み込み中…

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