Methanol, 1,1-diethoxy-, 1-acetate → 6-Fluoro-[1,2,4]triazolo[4,3-a]pyridine
反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][NH2:9])=[N:6][CH:7]=1.[C:10](OC(OCC)OCC)(=O)C>C1CCCCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:10]=[N:9][N:8]=2)[CH:7]=1参加物
4
実験手順
(5-Fluoro-pyridin-2-yl)-hydrazine (500 mg, 3.93 mmol) in diethoxymethyl acetate (5 mL) was stirred at RT for 2 h. The resulting precipitate was diluted with cyclohexane (5 mL) and filtered to give Intermediate Fa (379 mg, 70%). 1H NMR (400 MHz, CDCl3): 7.25 (1H, m), 7.84 (1H, m), 8.09 (1H, t, J=2.5 Hz), 8.84 (1H, s).
後処理
- filtrationfiltered
- customto give Intermediate Fa (379 mg, 70%)
出典と根拠
- ORDレコード
- ord-6393d376a55a4ea7ba21b4b22cbd189c
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09440974B2
反応ノート
読み込み中…