関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-(Phenoxymethyl)piperidine | HCID 3017444 | — |
| 反応物 | 2-Tert-butoxy-6-vinylpyrazine | HCID 22248276 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-Tert-butoxy-6-[2-(4-phenoxymethylpiperidino)ethyl]pyrazine | HCID 22248528 | — |
反応手順
After dissolving 471 mg of 2-tert-butoxy-6-vinylpyrazine and 505 mg of 4-(phenoxymethyl)piperidine in 10 ml of ethanol, the mixture was stirred for 4 days at 80° C. The reaction solution was concentrated under reduced pressure and the residue was purified by NH silica gel column chromatography (solvent: n-hexane/ethyl acetate) to obtain 2-tert-butoxy-6-[2-(4-phenoxymethylpiperidino)ethyl]pyrazine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07915274B2 |
|---|
| 出典データセット | uspto-grants-2011_03 |
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| ORD ID | ord-9e16f06448fc4f8fb6369ece4d7ea4d2 |
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| 出典メモ | uspto-grants-2011_03 |
|---|
