Water → 5-(Furan-2-yl)isoxazol-3-amine
反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[O:10][N:9]=[C:8](C(O)=O)[CH:7]=1.C1C=CC(P([N:28]=[N+]=[N-])(C2C=CC=CC=2)=O)=CC=1.O>C1C=CC=CC=1>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[O:10][N:9]=[C:8]([NH2:28])[CH:7]=1参加物
5
実験手順
To a solution of 2.0 g of 5-furan-2-yl-isoxazole-3-carboxylic acid and 6.2 mL of TEA in benzene was added 3.61 mL of DPPA at room temperature. After refluxing for 1.5 hrs, 30 mL of distilled water was added and then the resulting solution was refluxed for an additional 30 min. The reaction solution was concentrated under reduced pressure, and the concentrate was purified by column chromatography on silica gel to obtain 0.6 g of 5-furan-2-yl-isoxazol-3-ylamine (Yield: 40%).
後処理
- temperatureAfter refluxing for 1.5 hrs
- temperaturethe resulting solution was refluxed for an additional 30 min
- concentrationThe reaction solution was concentrated under reduced pressure
- customthe concentrate was purified by column chromatography on silica gel
出典と根拠
- ORDレコード
- ord-4ebb5004b63c4d4eaca013a6f286976e
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07915297B2
反応ノート
読み込み中…