1,2-Dichloroethane → N-(5-furan-2-yl-isoxazol-3-yl)-3-pyridin-2-yl-acrylamide

HRID 606282ノート

反応式

HRID 606282 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]=[CH:8][C:9]([OH:11])=O.[O:12]1[CH:16]=[CH:15][CH:14]=[C:13]1[C:17]1[O:21][N:20]=[C:19]([NH2:22])[CH:18]=1.C1C=CC2N(O)N=NC=2C=1.C(Cl)CCl>CN(C=O)C>[O:12]1[CH:16]=[CH:15][CH:14]=[C:13]1[C:17]1[O:21][N:20]=[C:19]([NH:22][C:9](=[O:11])[CH:8]=[CH:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[CH:18]=1

参加物

6

反応物 4

HCID 111,2-DichloroethaneHCID 757711-HydroxybenzotriazoleHCID 2478243-(2-Pyridyl)acrylic acidHCID 132302595-(Furan-2-yl)isoxazol-3-amine

生成物 1

HCID 67047568N-(5-furan-2-yl-isoxazol-3-yl)-3-pyridin-2-yl-acrylamide収率 36%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 6 mg of 3-pyridin-2-yl-acrylic acid and 6 mg of 5-furan-2-yl-isoxazol-3-ylamine in DMF were added 8 mg of HOBt, 9 mg of EDC and 0.014 mL of TEA. The reaction solution was stirred for 18 hrs at room temperature, followed by concentration under reduced pressure. The concentrate was purified by preparative HPLC to provide 4 mg of N-(5-furan-2-yl-isoxazol-3-yl)-3-pyridin-2-yl-acrylamide. (Yield: 36%).

後処理

  1. concentrationfollowed by concentration under reduced pressure
  2. customThe concentrate was purified by preparative HPLC

出典と根拠

ORDレコード
ord-b668bced9f59491b94c4f4a2666273b0
出典データセット
uspto-grants-2011_03
特許番号
US07915297B2

反応ノート

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