6-Methoxy-1,2,3,4-tetrahydronaphthalen-1-ol → 7-Methoxy-1,2-dihydronaphthalene

HRID 606356

反応式

HRID 606356 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9](O)[CH2:8][CH2:7][CH2:6]2>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10]([CH:9]=[CH:8][CH2:7][CH2:6]2)=[CH:11][CH:12]=1

参加物

3

反応物 1

HCID 110522116-Methoxy-1,2,3,4-tetrahydronaphthalen-1-ol

生成物 1

HCID 5947787-Methoxy-1,2-dihydronaphthalene収率 96%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
115 °C

実験手順

Crude 6-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol (10.3 g, 0.058 mol) was dissolved in 100 ml of toluene and heated in an oil bath (115° C.). P-tolylsulphonic acid (20 mg) was added to the reaction mixture and it was refluxed for about 1 h. The reaction was monitored by GC. The reaction mixture was then cooled and washed with sat. NaHCO3 solution, water and brine and organic layer was dried over Na2SO4. Concentration gave 8.879 of light brown oil. Yield 96%.

後処理

  1. temperaturewas refluxed for about 1 h
  2. temperatureThe reaction mixture was then cooled
  3. washwashed with sat. NaHCO3 solution, water and brine and organic layer
  4. dry with materialwas dried over Na2SO4
  5. concentrationConcentration
  6. customgave 8.879 of light brown oil

出典と根拠

ORDレコード
ord-22b350368a154bf89a87ab4c815cb4f1
出典データセット
uspto-grants-2011_03
特許番号
US07915295B2

関連ノート

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