関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 4-(Methylsulfinyl)phenol | HCID 151936 | — |
| 反応物 | 5-Bromo-2-nitropyridine | HCID 817620 | — |
| 生成物 | 5-(4-Methanesulfinyl-phenoxy)-2-nitro-pyridine | HCID 59686991 | 62.7% |
反応手順
To a solution of 4-methanesulfinyl-phenol (1.52 g, 9.7 mmol) in DMF (30 ml) cesium carbonate (4.2 g, 12.9 mmol) was added, followed by addition of 5-bromo-2-nitro pyridine (1.75 g, 8.6 mmol) and the mixture was stirred at 50° C. over night. The suspension was filtered and evaporated+co-evaporated with toluene. The compound was purified by chromatography (0→10% EtOH in Methylene chloride) to give 1.5 g (56%) of 5-(4-Methanesulfinyl-phenoxy)-2-nitro-pyridine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07915295B2 |
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| 出典データセット | uspto-grants-2011_03 |
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| ORD ID | ord-7fe3a4269f3e4b128e11fe13bb3e7401 |
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| 出典メモ | uspto-grants-2011_03 |
|---|
