HCID 178509869、化合物 → HCID 178509870、化合物
反応式
[NH:1]1[CH:5]=[N:4][C:3]([S:6][CH2:7][CH2:8][O:9][C:10]2[CH:11]=[C:12]([CH:15]=[CH:16][CH:17]=2)[C:13]#[N:14])=[N:2]1>N.CO.[Ni]>[NH:1]1[CH:5]=[N:4][C:3]([S:6][CH2:7][CH2:8][O:9][C:10]2[CH:11]=[C:12]([CH2:13][NH2:14])[CH:15]=[CH:16][CH:17]=2)=[N:2]1参加物
4
実験手順
A solution of 3-{[2-(1H-1,2,4-triazol-3-ylthio)ethyl]oxy}benzonitrile obtained in Reference Example 2 (9.00 g, 36.5 mmol) and Raney-nickel (5.00 g) in 5N ammonia/methanol (300 mL) was stirred at room temperature overnight under hydrogen atmosphere (1 atm). The catalyst was filtered off, and the filtrate was concentrate. The obtained residue was crystallized from toluene to give the title compound as a pale-blue powder (6.45 g, 71%).
後処理
- filtrationThe catalyst was filtered off
- concentrationthe filtrate was concentrate
- customThe obtained residue was crystallized from toluene
出典と根拠
- ORDレコード
- ord-1d70a8ac2cd844139fb9f697eadfb599
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07915267B2
反応ノート
読み込み中…