Sodium ethoxide → HCID 178470798、化合物
反応式
[NH2:1][C:2]([NH:4][NH:5][C:6](=O)[CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])=[S:3].[O-]CC.[Na+]>C(O)C>[SH:3][C:2]1[NH:4][N:5]=[C:6]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:1]=1参加物
4
反応条件
- 温度
- 80 °C
実験手順
A suspension of ethyl 3-[2-(aminocarbonothioyl)hydrazino]-3-oxopropanoate (14.0 g, 68.2 mmol) and sodium ethoxide (9.52 g, 140 mmol) in ethanol (200 mL) was stirred at 80° C. for 15 hr. The mixture was concentrated under reduced pressure, and the residue was acidified with 1N hydrochloric acid, and extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over sodium sulfate, and concentrated to give the title compound as an orange powder (12.2 g, 96%).
後処理
- concentrationThe mixture was concentrated under reduced pressure
- extractionextracted with ethyl acetate
- washThe organic layer was washed with saturated brine
- dry with materialdried over sodium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-1545db3bcd9e4b34940f1454171f0982
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07915267B2
反応ノート
読み込み中…