HCID 178470798、化合物 → HCID 178470784、化合物

HRID 606447ノート

反応式

HRID 606447 の反応式
S[C:2]1[NH:6][N:5]=[C:4]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:3]=1>C(O)C.[Ni]>[NH:6]1[CH:2]=[N:3][C:4]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])=[N:5]1

参加物

4

反応物 1

HCID 178470798HCID 178470798、化合物

生成物 1

HCID 178470784HCID 178470784、化合物収率 54%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

A suspension of ethyl (5-mercapto-1H-1,2,4-triazol-3-yl)acetate obtained in Reference Example 13 (2.00 g, 10.7 mmol) and Raney-nickel (5.00 g) in ethanol (20 mL) was stirred at 80° C. for 15 hr. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure. To a suspension of the residue in ethyl acetate was added activated carbon, and the mixture was filtered. the filtrate was concentrated under reduced pressure to give the title compound as a pale-green powder (900 mg, 54%).

後処理

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. additionTo a suspension of the residue in ethyl acetate
  4. additionwas added
  5. filtrationthe mixture was filtered
  6. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-ec6dbe2a7c114de798dddae17acccc3d
出典データセット
uspto-grants-2011_03
特許番号
US07915267B2

反応ノート

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