Hydrazine → ethyl (5-oxo-2,5-dihydro-1H-pyrazol-3-yl)acetate
反応式
O=[C:2]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH2:3][C:4](OCC)=[O:5].[NH2:15][NH2:16]>CCO>[O:5]=[C:4]1[NH:16][NH:15][C:2]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:3]1参加物
4
反応条件
- 温度
- 80 °C
実験手順
To a solution of diethyl 3-oxopentanedioate (26.0 g, 129 mmol) in EtOH (250 mL) was added hydrazine (4.38 g, 129 mmol) at room temperature, and the mixture was stirred at 80° C. for 3 hr. The reaction mixture was concentrated under reduced pressure, and the residue was crystallized from diethyl ether-hexane to give the title compound as a white powder (9.79 g, 45%).
後処理
- concentrationThe reaction mixture was concentrated under reduced pressure
- customthe residue was crystallized from diethyl ether-hexane
出典と根拠
- ORDレコード
- ord-9afd592fc70c4c1188bf37f1705bcb17
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07915267B2
反応ノート
読み込み中…