2-Benzofurancarboxylic acid, 5-methoxy-, ethyl ester → Ethyl 5-hydroxybenzofuran-2-carboxylate

HRID 606580

反応式

HRID 606580 の反応式
C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:8][C:7]=2[CH:16]=1>ClCCl>[OH:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:8][C:7]=2[CH:16]=1

参加物

3

反応物 1

HCID 5212832-Benzofurancarboxylic acid, 5-methoxy-, ethyl ester

生成物 1

HCID 22228632Ethyl 5-hydroxybenzofuran-2-carboxylate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

Ethyl 5-methoxybenzofuran carboxylate (22.7 mmol) was dissolved in dichlormethane (20 ml) and a 1.0 M solution of boron tribromide methyl sulphide complex in dichloromethane (68.1 mmol) was added. The mixture was heated at reflux over night The solvent was evaporated under vacuo and the residue purified by flash chromatography to obtain ethyl 5-hydroxybenzofuran carboxylate as a white solid.

後処理

  1. temperatureThe mixture was heated
  2. temperatureat reflux over night The solvent
  3. customwas evaporated under vacuo
  4. customthe residue purified by flash chromatography

出典と根拠

ORDレコード
ord-9919d0ed1faa48e0997bfb8a70d6c37d
出典データセット
uspto-grants-2011_03
特許番号
US07915300B2

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