Ethyl 5-methoxy-3-methyl-1-benzofuran-2-carboxylate → Ethyl 5-hydroxy-3-methyl-1-benzofuran-2-carboxylate
反応式
[CH3:1][C:2]1[C:6]2[CH:7]=[C:8]([O:11]C)[CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[C:13]([O:15][CH2:16][CH3:17])=[O:14]>ClCCl>[CH3:1][C:2]1[C:6]2[CH:7]=[C:8]([OH:11])[CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[C:13]([O:15][CH2:16][CH3:17])=[O:14]参加物
3
実験手順
Ethyl 3-methyl-5-methoxybenzofuran carboxylate (8.53 mmol) was dissolved in dichloromethane (10 ml) and a 1.0 M solution of boron tribromide methyl sulphide complex in dichloromethane (25.59 mmol) was added. The mixture was heated at reflux over night. The solvent was evaporated under vacuo and the residue purified by flash chromatography to obtain ethyl 3-methyl-5-hydroxybenzofuran carboxylate as a white solid.
後処理
- temperatureThe mixture was heated
- temperatureat reflux over night
- customThe solvent was evaporated under vacuo
- customthe residue purified by flash chromatography
出典と根拠
- ORDレコード
- ord-6ebdd579a1994699bfb77be6cea168e5
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07915300B2
反応ノート
読み込み中…