3-Methyl-4-(5-morpholin-4-ylmethyl-furan-2-yl)-benzoic acid methyl ester → 3-Methyl-4-(5-morpholin-4-ylmethyl-furan-2-yl)-benzoic acid
反応式
C[O:2][C:3](=[O:23])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:11][C:12]([CH2:15][N:16]3[CH2:21][CH2:20][O:19][CH2:18][CH2:17]3)=[CH:13][CH:14]=2)=[C:6]([CH3:22])[CH:5]=1>Cl>[CH3:22][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[C:10]1[O:11][C:12]([CH2:15][N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)=[CH:13][CH:14]=1)[C:3]([OH:23])=[O:2]参加物
3
実験手順
This ester (0.51 mmol) was heated to 70° C. in 18% HCl for 2 h at which point HPLC showed all the starting material to have been hydrolysed. The reaction was cooled and the product that precipitated out of solution was collected by filtration as a white solid. With no further purification this was coupled using the standard procedure.
後処理
- temperatureThe reaction was cooled
- customthe product that precipitated out of solution