Tributyltin Chloride → 1-Methyl-4-(tributylstannyl)-1H-imidazole

HRID 606765ノート

反応式

HRID 606765 の反応式
I[C:2]1[N:3]=[CH:4][N:5]([CH3:7])[CH:6]=1.CC[Mg+].[Br-].[Sn:12](Cl)([CH2:21][CH2:22][CH2:23][CH3:24])([CH2:17][CH2:18][CH2:19][CH3:20])[CH2:13][CH2:14][CH2:15][CH3:16]>C(Cl)Cl>[CH2:21]([Sn:12]([CH2:13][CH2:14][CH2:15][CH3:16])([CH2:17][CH2:18][CH2:19][CH3:20])[C:2]1[N:3]=[CH:4][N:5]([CH3:7])[CH:6]=1)[CH2:22][CH2:23][CH3:24]

参加物

5

反応物 3

HCID 15096Tributyltin ChlorideHCID 27734634-Iodo-1-methyl-1H-imidazoleHCID 178461630HCID 178461630、化合物

生成物 1

HCID 219011411-Methyl-4-(tributylstannyl)-1H-imidazole

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 4-iodo-1-methylimidazole (0.424 g, 2.04 mmol) in CH2Cl2 at rt was added EtMgBr (3.0 M in Et2O, 0.75 mL, 2.25 mmol) and the resulting solution was allowed to stir for 30 min at rt. To this solution was then added Bu3SnCl (0.60 mL, 2.21 mmol) and the mixture was stirred for another 7 h. The resulting mixture was then washed (sat. NH4C1, H2O, brine), dried (Na2SO4) and evaporated to give the title compound, which was used directly in the following step without further purification:

後処理

  1. washThe resulting mixture was then washed (sat. NH4C1, H2O, brine)
  2. dry with materialdried (Na2SO4)
  3. customevaporated

出典と根拠

ORDレコード
ord-1f3d29f8c7894ad3968306321295ad7c
出典データセット
uspto-grants-2011_03
特許番号
US07915283B2

反応ノート

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