関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Benzene, 1-bromo-3-(trifluoromethyl)- | HCID 9817 | — |
| 反応物 | Trimethylsilylacetylene | HCID 66111 | — |
| 触媒 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 触媒 | HCID 178419050 | HCID 178419050 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 1-[(Trimethylsilyl)ethynyl]-3-(trifluoromethyl)benzene | HCID 4281885 | 102.2% |
反応手順
Add copper (I) iodide (48.2 mg, 0.25 mmol), bis(triphenylphosphine)palladium (II) dichloride (155.8 m g, 0.22 mmol) and triethylamine (2.51 mL, 17.8 mmol), to a solution of 1-bromo-3-trifluoromethylbenzene (0.62 mL, 4.44 mmol) and trimethylsilylacetylene (0.81 mL, 5.78 mmol), in ethyl acetate (4 mL). Stir at 50° C. for 18h. Cool the reaction mixture to room temperature, concentrate and purify the residue by silica gel chromatography, eluting with hexanes, to give the title compound (1.1 g, 100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07915424B2 |
|---|
| 出典データセット | uspto-grants-2011_03 |
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| ORD ID | ord-f63577125a7149d4866ada36ec1221d8 |
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| 出典メモ | uspto-grants-2011_03 |
|---|
