Hydrochloric Acid → 1-Ethynyl-3-(trifluoromethyl)benzene
反応式
C(=O)([O-])[O-].[K+].[K+].C[Si](C)(C)[C:9]#[C:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=1.Cl>C(O)C>[C:10]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:18])([F:19])[F:20])[CH:12]=1)#[CH:9]参加物
5
実験手順
Add potassium carbonate (307 mg, 2.22 mmol) to a solution of trimethyl-(3-trifluoromethylphenylethynyl)-silane (1.07 g, 4.42 mmol) in ethanol (15 mL). Stir at room temperature for 16 h. Neutralized with 10% aqueous hydrochloric acid solution. Add water and extract the product with hexanes. Evaporate hexanes slowly in a cool water bath (<15° C.) to give the title compound (580 mg, 77%).
後処理
- extractionAdd water and extract the product with hexanes
出典と根拠
- ORDレコード
- ord-27d7747c2c7e4b2282c127c635a7efd1
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07915424B2
反応ノート
読み込み中…