Hydrochloric Acid → 3-Methyl-5-phenylethynylpyridine hydrochloride
反応式
[ClH:1].[CH3:2][C:3]1[CH:4]=[N:5][CH:6]=[C:7]([C:9]#[C:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:8]=1>O1CCOCC1.C(OCC)C>[ClH:1].[CH3:2][C:3]1[CH:4]=[N:5][CH:6]=[C:7]([C:9]#[C:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:8]=1参加物
5
実験手順
Add a 4 N solution of hydrogen chloride in 1,4-dioxane (0.6 mL) to a solution of 3-methyl-5-phenylethynylpyridine (0.398 g, 2.06 mmol), (prepared essentially as described in EXAMPLE 1), in diethyl ether (2 mL). Concentrate the reaction mixture and triturate the resulting solid with hexanes and diethyl ether to give the title compound as a solid (0.477 mg, 100%).
後処理
- custom(prepared essentially
- concentrationConcentrate the reaction mixture
- customtriturate the resulting solid with hexanes and diethyl ether
出典と根拠
- ORDレコード
- ord-5ce516976ecf47aeacdc404f9ef9b176
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07915424B2
反応ノート
読み込み中…