Hydrochloric Acid → 3-Bromo-5-(4-fluorophenylethynyl)-pyridine hydrochloride
反応式
[ClH:1].[Br:2][C:3]1[CH:4]=[N:5][CH:6]=[C:7]([C:9]#[C:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[CH:8]=1>C(OCC)C>[ClH:1].[Br:2][C:3]1[CH:4]=[N:5][CH:6]=[C:7]([C:9]#[C:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[CH:8]=1参加物
4
実験手順
Add 1 M hydrogen chloride in diethyl ether (1.1 eq) to 3-bromo-5-(4-fluorophenylethynyl)-pyridine, from PREPARATION 24, in diethyl ether and stir for 2 h. Filter and dry the collected solid under high vacuum to give the title compound.
後処理
- customfrom PREPARATION 24
- filtrationFilter
- customdry the collected solid under high vacuum
出典と根拠
- ORDレコード
- ord-1a0de6886ecf4be6a0bcda3e56eff07e
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07915424B2
反応ノート
読み込み中…