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2-Fluoro-5-trimethylsilanylethynyl-phenylamine → 5-(3-Amino-4-fluorophenylethynyl)-nicotinonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Fluoro-5-trimethylsilanylethynyl-phenylamine | HCID 67047696 | — |
| 反応物 | 3-Bromonicotinonitrile | HCID 67047774 | — |
| 生成物 | 5-(3-Amino-4-fluorophenylethynyl)-nicotinonitrile | HCID 67047822 | 65% |
反応手順
Prepare essentially as described in EXAMPLE 138 using 3-bromonicotinonitrile (3.4 g, 18.3 mmol) and 2-fluoro-5-trimethylsilanylethynyl-phenylamine, (prepared as described in PREPARATION 41), (3.8 g, 18.3 mmol) to give the title compound as a white solid (2.8 g, 65%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07915424B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-00547915240f429085bf9f6c5be4190d |
| 出典メモ | uspto-grants-2011_03 |