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1-Chloro-4-iodobenzene → 5-[2-(4-Chlorophenyl)-vinyl]-nicotinonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Chloro-4-iodobenzene | HCID 12510 | — |
| 反応物 | Tri-o-tolylphosphine | HCID 80271 | — |
| 反応物 | 5-Vinylnicotinonitrile | HCID 67047575 | — |
| 触媒 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 触媒 | palladium(II) acetate | HCID 167845 | — |
| 生成物 | 5-[2-(4-Chlorophenyl)-vinyl]-nicotinonitrile | HCID 67048195 | 70% |
反応手順
Prepare essentially as described in EXAMPLE 15 using palladium(II) acetate (0.002 g, 0.01 mmol), tri-o-tolylphosphine (0.06 g, 0.02 mmol), copper (I) iodide (0.001 g, 0.005 mmol), 1-chloro-4-iodobenzene (0.24 g, 1 mmol) and 5-vinylnicotinonitrile, (prepared essentially as described in PREPARATION 51), (0.195 g, 1.5 mmol) at 100° C. for 7 h to give the title compound (0.170 g, 70%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07915424B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-bf805bd5f1ef42e6b63041659f94d86f |
| 出典メモ | uspto-grants-2011_03 |