Iodine → HCID 67065998、化合物
反応式
[I:1]I.[CH3:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])=[C:7]([F:18])[CH:6]=1>CO.S([O-])([O-])(=O)=O.[Ag+2]>[CH3:3][O:4][C:5]1[C:10]([I:1])=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])=[C:7]([F:18])[CH:6]=1参加物
5
実験手順
To a mixture of silver sulfate (0.34 g, 1.11 mmol), iodine (0.28 g, 1.11 mmol) in MeOH (10 ml) at room temperature, a solution of 2-fluoro-2′-methylbiphenyl-4-yl methyl ether from above (0.24 g, 1.11 mmol) in MeOH (5 ml) was added dropwise. The mixture was stirred at room temperature for 4 h until the color turned to light yellow. The solid was filtered off and the filtrate was concentrated. The residue was purified via flash column using hexane as the eluant to give the title compound.
後処理
- filtrationThe solid was filtered off
- concentrationthe filtrate was concentrated
- customThe residue was purified via flash column
出典と根拠
- ORDレコード
- ord-08e82a03727345aa8f7ad123568aa190
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07915271B2
反応ノート
読み込み中…