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2-(4-Fluoro-phenylsulfanyl)-5-methyl-phenylamine → (7-Cyclopropyl-pyrido[2,3-d]pyrimidin-4-yl)-[2-(4-fluoro-phenylsulfanyl)-5-methyl-phenyl]-amine

HRID 607235
ノート
印刷プレビュー

反応式

HRID 607235 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][C:10]=2[NH2:16])=[CH:4][CH:3]=1.C([C:19]1[C:20]([N:28]=[CH:29][N:30]([CH3:32])C)=[N:21][C:22]([CH:25]2[CH2:27][CH2:26]2)=[CH:23][CH:24]=1)#N.NC1C=C(C)C=CC=1SC1C=CC(O)=CC=1.C(C1C(N=CN(C)C)=NC(C)=CC=1)#N>>[CH:25]1([C:22]2[CH:23]=[CH:24][C:19]3[C:32]([NH:16][C:10]4[CH:11]=[C:12]([CH3:15])[CH:13]=[CH:14][C:9]=4[S:8][C:5]4[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=4)=[N:30][CH:29]=[N:28][C:20]=3[N:21]=2)[CH2:26][CH2:27]1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 4

HCID 431689322-(4-Fluoro-phenylsulfanyl)-5-methyl-phenylamine2 回HCID 668081234-(2-Amino-4-methyl-phenylsulfanyl)-phenolHCID 66808412N'-(3-Cyano-6-cyclopropyl-pyridin-2-yl)-N,N-dimethyl-formamidine2 回HCID 66808573N'-(3-Cyano-6-methyl-pyridin-2-yl)-N,N-dimethyl-formamidine

生成物 1

HCID 66808336(7-Cyclopropyl-pyrido[2,3-d]pyrimidin-4-yl)-[2-(4-fluoro-phenylsulfanyl)-5-methyl-phenyl]-amine

実験手順

2-(4-Fluoro-phenylsulfanyl)-5-methyl-phenylamine was reacted with the product from Example 119A using the procedure from Example 102 substituting 2-(4-Fluoro-phenylsulfanyl)-5-methyl-phenylamine for the product from Example 6c and substituting the product from Example 119A for the product from Example 10B to provide the crude residue which was purified by trituration with methanol to provide the title compound. 1H NMR (300 MHz, DMSO-D6) δ ppm: 0.96-1.19 (m, J=6.25 Hz, 4H), 2.22-2.42 (m, 1H), 2.33 (s, 3H), 7.02-7.28 (m, 6H), 7.33 (s, 1H), 7.56 (d, J=8.46 Hz, 1H), 8.46 (s, 1H), 8.66 (d, J=8.09 Hz, 1H), 10.03 (s, 1H); MS (ESI)+ m/z 403 (M+H)+.

後処理

  1. customto provide the crude residue which
  2. customwas purified by trituration with methanol

出典と根拠

ORDレコード
ord-e75693b6c8a04afcbb09a25ff9c180f4
出典データセット
uspto-grants-2011_03
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07915411B2

反応ノート

読み込み中…

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