4-(2-Amino-4-methyl-phenylsulfanyl)-phenol → 4-[4-Benzyloxy-2-(pyrimido[4,5-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenol

HRID 607280ノート

反応式

HRID 607280 の反応式
[C:1]([C:3]1[C:4]([N:9]=[CH:10][N:11](C)C)=[N:5][CH:6]=[N:7][CH:8]=1)#[N:2].N[C:15]1[CH:20]=[C:19]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:18]=[CH:17][C:16]=1[S:29][C:30]1[CH:35]=[CH:34][C:33]([OH:36])=[CH:32][CH:31]=1.NC1C=C(C)C=CC=1SC1C=CC(O)=CC=1.C(C1C(N=CN(C)C)=NC(SCC)=NC=1)#N>>[CH2:22]([O:21][C:19]1[CH:18]=[CH:17][C:16]([S:29][C:30]2[CH:31]=[CH:32][C:33]([OH:36])=[CH:34][CH:35]=2)=[C:15]([NH:2][C:1]2[C:3]3[C:4](=[N:5][CH:6]=[N:7][CH:8]=3)[N:9]=[CH:10][N:11]=2)[CH:20]=1)[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

参加物

5

反応物 4

HCID 668081234-(2-Amino-4-methyl-phenylsulfanyl)-phenolHCID 66808339N'-(5-Cyano-pyrimidin-4-yl)-N,N-dimethyl-formamidine2 回HCID 668085974-(2-Amino-4-benzyloxy-phenylsulfanyl)-phenol2 回HCID 66808651N'-(5-Cyano-2-ethylsulfanyl-pyrimidin-4-yl)-N,N-dimethyl-formamidine

生成物 1

HCID 670479034-[4-Benzyloxy-2-(pyrimido[4,5-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenol

実験手順

The product from Example 194A was reacted with the product from Example 27A according to the procedure from Example 156C substituting the product from Example 27A for the product from Example 6c and substituting the product from Example 194A for the product from Example 156B to provide the crude product which was purified by HPLC with NH4OAc to provide the title compound. 1H NMR (300 MHz, DMSO-D6) δ ppm: 5.10 (s, 2H), 6.63 (d, J=8.46 Hz, 2H), 6.94-7.05 (m, 1H), 7.10 (d, J=8.82 Hz, 2H), 7.18 (d, J=7.72 Hz, 2H), 7.29-7.51 (m, 5H), 9.05 (m, 1H), 9.63 (s, 1H), 9.92 (s, 1H), 10.66 (s, 1H); MS (ESI−) m/z 452 (M−H)−.

後処理

  1. customto provide the crude product which
  2. customwas purified by HPLC with NH4OAc

出典と根拠

ORDレコード
ord-a6510ea9649d4c85ae60dbdbed4e07f7
出典データセット
uspto-grants-2011_03
特許番号
US07915411B2

反応ノート

読み込み中…