Dimethylformamide dimethyl acetal → N'-(3-Cyano-6-isopropyl-pyrazin-2-yl)-N,N-dimethyl-formamidine

HRID 607328ノート

反応式

HRID 607328 の反応式
[NH2:1][C:2]1[C:3]([C:11]#[N:12])=[N:4][CH:5]=[C:6]([CH:8]([CH3:10])[CH3:9])[N:7]=1.CO[CH:15](OC)[N:16]([CH3:18])[CH3:17]>C1(C)C=CC=CC=1>[C:11]([C:3]1[C:2]([N:1]=[CH:15][N:16]([CH3:18])[CH3:17])=[N:7][C:6]([CH:8]([CH3:10])[CH3:9])=[CH:5][N:4]=1)#[N:12]

参加物

4

反応物 2

HCID 78373Dimethylformamide dimethyl acetalHCID 451224093-Amino-5-isopropylpyrazine-2-carbonitrile

生成物 1

HCID 66808405N'-(3-Cyano-6-isopropyl-pyrazin-2-yl)-N,N-dimethyl-formamidine収率 100.9%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of the product from Example 244B (0.37 g, 2.28 mmol) and dimethylformamide dimethylacetal (0.30 g, 2.5 mmol, 1.1 eq) in toluene (25 mL) was heated under reflux for 1.75 h. The reaction mixture was then cooled to room temperature and the solvent evaporated under reduced pressure to provide the title compound (0.50 g, 100%) as a thick red/brown oil that was used in subsequent reactions without further purification.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 1.75 h
  3. customthe solvent evaporated under reduced pressure

出典と根拠

ORDレコード
ord-85a837887aca4eb4bebd7c9770ff41fd
出典データセット
uspto-grants-2011_03
特許番号
US07915411B2

反応ノート

読み込み中…