化工社化工社 化学情報印刷レポート · 研究参考用
Thiomorpholine 1,1-dioxide → (S)-N-{[3-(1,1-dioxidothiomorpholin-4-yl)propyl](oxido)phenyl--sulfanylidene}-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thiomorpholine 1,1-dioxide | HCID 6484228 | — |
| 反応物 | N-[(3-bromopropyl)(oxido)phenyl--sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide | HCID 76585264 | — |
| 生成物 | (S)-N-{[3-(1,1-dioxidothiomorpholin-4-yl)propyl](oxido)phenyl--sulfanylidene}-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide | HCID 57657888 | — |
反応手順
In a manner similar to that described for Example 508, N-[(3-bromopropyl)(oxido)phenyl--sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide and thiomorpholine-1,1-dioxide were converted to the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07915443B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-99f8ef1589184e79bd08e12e9a53808f |
| 出典メモ | uspto-grants-2011_03 |