Chloroacetone → tert-butyl [(1R)-1-(4-methyl-1,3-thiazol-2-yl)ethyl]carbamate

HRID 607617

反応式

HRID 607617 の反応式
[NH2:1][C:2](=[S:13])[C@H:3]([NH:5][C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9])[CH3:4].Cl[CH2:15][C:16](=O)[CH3:17]>C(O)C>[CH3:17][C:16]1[N:1]=[C:2]([C@H:3]([NH:5][C:6](=[O:12])[O:7][C:8]([CH3:9])([CH3:11])[CH3:10])[CH3:4])[S:13][CH:15]=1

参加物

4

反応物 2

HCID 6571ChloroacetoneHCID 5324342tert-butyl [(1R)-2-amino-1-methyl-2-thioxoethyl]carbamate

生成物 1

HCID 59216334tert-butyl [(1R)-1-(4-methyl-1,3-thiazol-2-yl)ethyl]carbamate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

A mixture of tert-butyl [(1R)-2-amino-1-methyl-2-thioxoethyl]carbamate (100 mg, 0.49 mmol) with 3 equivalents of chloroacetone (0.135 g) in ethanol (1 mL) was heated at 80° C. for 2 h. After cooling, the solution was concentrated. The residue was dissolved in DCM (1 ml). To the solution was added TFA (1 mL). The mixture was stirred at RT for 30 min. The volatiles were removed under reduced pressure to yield desired product.

後処理

  1. temperatureAfter cooling
  2. concentrationthe solution was concentrated
  3. dissolutionThe residue was dissolved in DCM (1 ml)
  4. additionTo the solution was added TFA (1 mL)
  5. customThe volatiles were removed under reduced pressure

出典と根拠

ORDレコード
ord-4fefd6104feb46b1a8729669818232bf
出典データセット
uspto-grants-2011_03
特許番号
US07915408B2

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