(Bis(2-methoxyethyl)amino)sulfur trifluoride → N-(((2S,4S)-1-(biphenylcarbonyl)-4-fluoropyrrolidin-2-yl)methyl)quinoline-8-carboxamide

HRID 60787

反応式

HRID 60787 の反応式
[C:1]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:2]([C:7]([N:9]2[CH2:13][C@H:12](O)[CH2:11][C@H:10]2[CH2:15][NH:16][C:17]([C:19]2[CH:20]=[CH:21][CH:22]=[C:23]3[C:28]=2[N:27]=[CH:26][CH:25]=[CH:24]3)=[O:18])=[O:8])=[CH:3][CH:4]=[CH:5][CH:6]=1.COCCN(S(F)(F)[F:45])CCOC>C(Cl)Cl>[C:1]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:2]([C:7]([N:9]2[CH2:13][C@@H:12]([F:45])[CH2:11][C@H:10]2[CH2:15][NH:16][C:17]([C:19]2[CH:20]=[CH:21][CH:22]=[C:23]3[C:28]=2[N:27]=[CH:26][CH:25]=[CH:24]3)=[O:18])=[O:8])=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 2734690(Bis(2-methoxyethyl)amino)sulfur trifluorideHCID 89739415N-(((2S,4R)-1-(biphenylcarbonyl)-4-hydroxypyrrolidin-2-yl)methyl)quinoline-8-carboxamide

生成物 1

HCID 71715839N-(((2S,4S)-1-(biphenylcarbonyl)-4-fluoropyrrolidin-2-yl)methyl)quinoline-8-carboxamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
-78 °C

実験手順

A mixture of N-(((2S,4R)-1-(biphenylcarbonyl)-4-hydroxypyrrolidin-2-yl)methyl)quinoline-8-carboxamide (0.045 g, 0.10 mmol) in DCM was cooled to −78° C., added with bis(2-methoxyethyl)aminosulfur trifluoride (Aldrich) (41 μL, 0.22 mmol) dropwise. The resulting solution was stirred at −78° C. for 0.5 h, allowed to warm to rt gradually over 1.5 h and stirred at rt for 0.5 h, which was quenched by slow addition of MeOH and purified by preparative HPLC using acetonitrile and water (0.1% TFA) as eluent to provide N-(((2S,4S)-1-(biphenylcarbonyl)-4-fluoropyrrolidin-2-yl)methyl)quinoline-8-carboxamide as a white solid. MS (ESI) 454.14 (M+H).

後処理

  1. temperatureto warm to rt gradually over 1.5 h
  2. stirringstirred at rt for 0.5 h
  3. customwhich was quenched by slow addition of MeOH
  4. custompurified by preparative HPLC

出典と根拠

ORDレコード
ord-70bdcca6c67e416c95b9e9b78f4f3bf0
出典データセット
uspto-grants-2016_09
特許番号
US09440982B2

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