2-methyl-5-phenyl-1,3-thiazole-4-carboxylic Acid → rac-cis-(2-(Aminomethyl)-3-methylpiperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

HRID 60795ノート

反応式

HRID 60795 の反応式
[CH3:1][C@H:2]1[CH2:7][CH2:6][CH2:5][NH:4][C@H:3]1[CH2:8][NH:9]C(=O)OC(C)(C)C.[CH3:17][C:18]1[S:19][C:20]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[C:21]([C:23](O)=[O:24])[N:22]=1>>[NH2:9][CH2:8][C@H:3]1[C@@H:2]([CH3:1])[CH2:7][CH2:6][CH2:5][N:4]1[C:23]([C:21]1[N:22]=[C:18]([CH3:17])[S:19][C:20]=1[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1)=[O:24]

参加物

3

反応物 2

HCID 9435352-methyl-5-phenyl-1,3-thiazole-4-carboxylic AcidHCID 95378400cis-N-Boc-1-(3-methylpiperidin-2-YL)methanamine

生成物 1

HCID 131737123rac-cis-(2-(Aminomethyl)-3-methylpiperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

実験手順

The title compound was synthesized following the same general protocol as described in Example 11 using rac-cis-tert-butyl ((3-methylpiperidin-2-yl)methyl)carbamate and 2-methyl-5-phenylthiazole-4-carboxylic acid. MS (ESI) 330.08 (M+H).

出典と根拠

ORDレコード
ord-2bba2d6b6aaa4105b761dc08b5fc89f7
出典データセット
uspto-grants-2016_09
特許番号
US09440982B2

反応ノート

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