化工社化工社 化学情報印刷レポート · 研究参考用
HRID 60798作成日：2026年10月25日
Diisopropylethylamine → rac-cis-(2-(((5-Ethylpyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone
https://huagongshe.com/reaction/60798
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 2-Chloro-5-ethylpyrimidine | HCID 3572763 | — |
| 反応物 | Rac-cis-(2-(aminomethyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone | HCID 117727897 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | rac-cis-(2-(((5-Ethylpyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone | HCID 131737126 | — |
反応手順
A mixture of rac-cis-(2-(aminomethyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone, 5-ethyl-2-chloropyrimidine, and DIPEA in isopropanol was stirred at 110° C. for 18 h. The reaction was cooled and concentrated in vacuo. The crude reaction mixture was purified by reverse-phase preparative HPLC to afford the title compound. MS (ESI) 454.02 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US09440982B2 |
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| 出典データセット | uspto-grants-2016_09 |
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| ORD ID | ord-aa260a00d23b419894ac9bc950ccb827 |
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| 出典メモ | uspto-grants-2016_09 |
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