Potassium Hydroxide → HCID 178418656、化合物
反応式
C([O:3][C:4](=[S:18])[CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH2:6][C:7]([CH3:10])([CH3:9])[CH3:8])C.[OH-].[K+]>CO>[CH2:11]([CH:5]([CH2:6][C:7]([CH3:10])([CH3:9])[CH3:8])[C:4]([OH:3])=[S:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1参加物
4
実験手順
400 mg of 2-benzyl-3-tert.-butylthiopropionic acid ethyl ester was dissolved in 1.5 ml of methanol and then reacted with 5 ml of 2N potassium hydroxide solution. The mixture was stirred overnight at room temperature and concentrated by evaporation. The residue was diluted with water and washed with ether. The aqueous layer was acidified to pH 3 with 2N HCl, and then evaporated to give the title compound (280 mg, 78% yield). 1H NMR: 300 MHz spectrum consistent with proposed structure.
後処理
- concentrationconcentrated by evaporation
- additionThe residue was diluted with water
- washwashed with ether
- customevaporated
出典と根拠
- ORDレコード
- ord-27edfb5bfda24dc2817ffeeee268dc01
- 出典データセット
- uspto-grants-1993_09
- 特許番号
- US05246969
反応ノート
読み込み中…