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HRID 60856作成日：2026年10月26日

2,5-Dichloropyrimidine → rac-trans-(2-(((5-Chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone

https://huagongshe.com/reaction/60856

反応式

関与物質

役割名称HCID仕込み量
反応物2,5-DichloropyrimidineHCID 590641—
反応物rac-trans-(2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanoneHCID 131737142—
生成物rac-trans-(2-(((5-Chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanoneHCID 89741474—

反応手順

The title compound was prepared following the same general protocol as described for Example 16 using 2,5-dichloropyrimidine and rac-trans-(2-(aminomethyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone. MS (ESI) 460.4 (M+H).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09440982B2
出典データセットuspto-grants-2016_09
ORD IDord-6082887debae4031800af1ee49d6c407
出典メモuspto-grants-2016_09