N,N-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline → Biphenyl

HRID 608671ノート

反応式

HRID 608671 の反応式
CCn1c(=O)c2c(nc(N[C@@H]3CCC[C@H]3O)n2Cc2ccc(OC)c(Br)c2)n(CCO)c1=O.CN(C)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1.O=P(O)(O)O.[K]>CC(C)c1cc(C(C)C)c(-c2ccccc2[PH](C2CCCCC2)(C2CCCCC2)[Pd]2([O]S(C)(=O)=O)[NH]c3ccccc3-c3cccc[c]32)c(C(C)C)c1.CS(C)=O.O>CCn1c(=O)c2c(nc(N[C@@H]3CCC[C@H]3O)n2Cc2ccc(OC)c(-c3ccc(N(C)C)cc3)c2)n(CCO)c1=O

参加物

9

反応物 2

HCID 2758659N,N-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)anilineHCID 9871410Dasantafil

生成物 3

HCID 7095BiphenylHCID 9871410DasantafilHCID 178462858HCID 178462858、化合物

試薬・触媒・溶媒 4

HCID 178439024HCID 178439024、化合物触媒HCID 679Dimethyl Sulfoxide溶媒3 回HCID 962Water溶媒2 回HCID 16218557Phosphoric acid (potassium)その他

後処理

  1. additionAfter 22 hours the crude reactions were diluted with 3 x 1 uL 0.5 M AcOH in DMSO (containing PhPh as an internal standard). The reactions were mixed after each dispense operation.
  2. aliquotMosquito(R) was used to transfer 1 uL of each quenched reaction from the 1,536-well reaction plate to 384-well analytical plates containing 60 uL DMSO for analysis.

出典と根拠

ORDレコード
ord-e6f7f31837b34d5198ab22c70ae59b0e
出典データセット
Cernak miniaturized Suzuki Cross-Coupling 12x10 Informer Library
元リンク
出典を表示

反応ノート

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