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Sodium Hydroxide → rac-cis-Allyl 2-(((tert-butoxycarbonyl)amino)methyl)-3-methylpiperidine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Allyl chloroformate | HCID 18052 | — |
| 反応物 | cis-N-Boc-1-(3-methylpiperidin-2-YL)methanamine | HCID 95378400 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | rac-cis-Allyl 2-(((tert-butoxycarbonyl)amino)methyl)-3-methylpiperidine-1-carboxylate | HCID 131737149 | — |
反応手順
To the mixture of rac-cis-tert-butyl ((3-methylpiperidin-2-yl)methyl)carbamate (9.48 g, 41.53 mmol) in THF (25 mL) was added NaOH (2 M, 25 mL), followed by allyl chloroformate (6.65 mL, 62.3 mmol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09440982B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-b6d9eefc6b694479bdfc197219fb860b |
| 出典メモ | uspto-grants-2016_09 |