Methanol → Methyl 2-bromo-5-methylbenzoate

HRID 60888

反応式

HRID 60888 の反応式
[Br:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].OS(O)(=O)=O.[CH3:17]O>>[Br:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([O:6][CH3:17])=[O:5]

参加物

4

反応物 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 2280802-Bromo-5-methylbenzoic acid

生成物 1

HCID 15110996Methyl 2-bromo-5-methylbenzoate

反応条件

温度
100 °C

実験手順

2-Bromo-5-methylbenzoic acid (9.3 g, 43.4 mmol) was dissolved in MeOH (100 mL) and then cat. conc. H2SO4 was added. The mixture was refluxed at 100° C. overnight. The mixture was cooled to rt and the solvent was removed at reduced pressure. The crude residue was dissolved with EtOAc, and washed with water twice, followed by saturated NaHCO3 and brine, dried over anhydrous Na2SO4. The solvent was removed in vacuo to obtain the title compound with no further purification.

後処理

  1. temperatureThe mixture was cooled to rt
  2. customthe solvent was removed at reduced pressure
  3. dissolutionThe crude residue was dissolved with EtOAc
  4. washwashed with water twice
  5. dry with materialdried over anhydrous Na2SO4
  6. customThe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-f3beddf5a050465f840bd0014af2be0c
出典データセット
uspto-grants-2016_09
特許番号
US09440982B2

関連ノート

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