Methanol → Methyl 2-bromo-5-methylbenzoate
反応式
[Br:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].OS(O)(=O)=O.[CH3:17]O>>[Br:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([O:6][CH3:17])=[O:5]参加物
4
反応条件
- 温度
- 100 °C
実験手順
2-Bromo-5-methylbenzoic acid (9.3 g, 43.4 mmol) was dissolved in MeOH (100 mL) and then cat. conc. H2SO4 was added. The mixture was refluxed at 100° C. overnight. The mixture was cooled to rt and the solvent was removed at reduced pressure. The crude residue was dissolved with EtOAc, and washed with water twice, followed by saturated NaHCO3 and brine, dried over anhydrous Na2SO4. The solvent was removed in vacuo to obtain the title compound with no further purification.
後処理
- temperatureThe mixture was cooled to rt
- customthe solvent was removed at reduced pressure
- dissolutionThe crude residue was dissolved with EtOAc
- washwashed with water twice
- dry with materialdried over anhydrous Na2SO4
- customThe solvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-f3beddf5a050465f840bd0014af2be0c
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09440982B2
反応ノート
読み込み中…