N,N-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline → Biphenyl

反応式

CN(C)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1.O=C(NCc1ccc(F)cc1)c1nc(Br)c2cccnc2c1O.O=P(O)(O)O.[K]>CC(C)c1cc(C(C)C)c(-c2ccccc2[PH](C2CCCCC2)(C2CCCCC2)[Pd]2([O]S(C)(=O)=O)[NH]c3ccccc3-c3cccc[c]32)c(C(C)C)c1.CS(C)=O.O>CN(C)c1ccc(-c2nc(C(=O)NCc3ccc(F)cc3)c(O)c3ncccc23)cc1

参加物

後処理

additionAfter 22 hours the crude reactions were diluted with 3 x 1 uL 0.5 M AcOH in DMSO (containing PhPh as an internal standard). The reactions were mixed after each dispense operation.
aliquotMosquito(R) was used to transfer 1 uL of each quenched reaction from the 1,536-well reaction plate to 384-well analytical plates containing 60 uL DMSO for analysis.

出典と根拠

ORDレコード: ord-89c5e53c531041a8912ae6a67d1647d4
出典データセット: Cernak miniaturized Suzuki Cross-Coupling 12x10 Informer Library
DOI: 10.1038/s44160-023-00351-1
元リンク: 出典を表示

反応ノート

読み込み中…

参加物

反応物 2

HCID 2758659N,N-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

HCID 223464015-bromo-N-(4-fluorobenzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamide

生成物 3

HCID 7095Biphenyl

HCID 223464015-bromo-N-(4-fluorobenzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamide

HCID 178482693HCID 178482693、化合物

試薬・触媒・溶媒 4

HCID 178439024HCID 178439024、化合物触媒

HCID 679Dimethyl Sulfoxide溶媒3 回

HCID 962Water溶媒2 回

HCID 16218557Phosphoric acid (potassium)その他

後処理

additionAfter 22 hours the crude reactions were diluted with 3 x 1 uL 0.5 M AcOH in DMSO (containing PhPh as an internal standard). The reactions were mixed after each dispense operation.
aliquotMosquito(R) was used to transfer 1 uL of each quenched reaction from the 1,536-well reaction plate to 384-well analytical plates containing 60 uL DMSO for analysis.

出典と根拠

ORDレコード: ord-89c5e53c531041a8912ae6a67d1647d4
出典データセット: Cernak miniaturized Suzuki Cross-Coupling 12x10 Informer Library
DOI: 10.1038/s44160-023-00351-1
元リンク: 出典を表示

反応ノート

読み込み中…